Table 1.
Comparison of the pharmacokinetics of darunavir/ritonavir vs darunavir/cobicistat in HIV-infected subjects
| Parameters | Darunavir/ritonavir (800/100 mg) once daily34 | Darunavir/cobicistat (800/150 mg) once daily39 |
|---|---|---|
| Cmin (ng/mL) | 1,067±361 | 1,311±969 |
| Cmax (ng/mL) | 5,259±1,576 | 7,663±1,920 |
| AUC24 h (ng·h/mL) | 61,106±22,455 | 81,646±26,322 |
| Tmax (hours) (median, Q1, Q3) | N/A | 3.5 (2.48, 4.29) |
| T1/2 (hours) (median, Q1, Q3) | 14.4±5.17 (mean ± SD) | 7.24 (5.35, 11.54) |
Abbreviations: AUC, area under the curve; N/A, not available; SD, standard deviation; Cmin, minimum serum concentration; Cmax, maximum serum concentration; Tmax, time at which Cmax is observed; T1/2, half life.