Table 3.
Univariate analysis of survival
| Hazard ratio | 95% CI | P-value | |
|---|---|---|---|
| Age (years) | 1.04 | 0.97–1.11 | 0.23 |
| Male sex | 1.12 | 0.25–5.03 | 0.87 |
| SOFA score | 1.07 | 0.65–1.77 | 0.76 |
| APACHE II score | 1.05 | 0.91–1.21 | 0.48 |
| PaO2/F1O2(mmHg) | 1.00 | 0.99–1.00 | 0.69 |
| WBC (1/µL) | 1.00 | 0.99–1.00 | 0.96 |
| LDH (IU/L) | 1.00 | 0.99–1.00 | 0.67 |
| CRP (mg/dL) | 1.04 | 0.97–1.11 | 0.25 |
| BNP (pg/mL) | 1.00 | 1.00–1.00 | 0.051 |
| KL-6 (U/L) | 0.99 | 0.99–1.00 | 0.15 |
| SP-D (ng/mL) | 0.99 | 0.99–1.00 | 0.052 |
| FDP (µg/mL) | 0.98 | 0.85–1.12 | 0.78 |
| D-dimer (mg/mL) | 0.99 | 0.85–1.15 | 0.92 |
| TAT (ng/mL) | 0.98 | 0.95–1.02 | 0.51 |
| PIC (ng/mL) | 0.97 | 0.38–2.49 | 0.96 |
| BAL available (%) | 0.73 | 0.22–2.35 | 0.60 |
| Neutrophils in BAL (%) | 1.78 | 0.48–6.62 | 0.38 |
| Lymphocytes in BAL (%) | 0.75 | 0.56–1.01 | 0.060 |
| rhTM administration | 0.21 | 0.06–0.77 | 0.013* |
Note:
*
Cox proportional hazards’ regression models.
Abbreviations: CI, confidence interval; SOFA, sequential organ failure assessment; APACHE II, acute physiology and chronic health evaluation II; PaO2, oxygen partial pressure; WBC, white blood cell; LDH, lactate dehydrogenase; CRP, C-reactive protein; BNP, brain natriuretic peptide; KL-6, Krebs von den Lungen-6; SP-D, surfactant protein-D; FDP, fibrinogen degradation products; TAT, thrombin–antithrombin; PIC, plasmin–alpha 2-plasmin inhibitor complex; BAL, bronchoalveolar lavage; rhTM, recombinant human thrombomodulin; FIO2, fraction of inspired oxygen.