Table 2.
Summary effects in the overall and subgroup analyses.
| TEST OF ASSOCIATION
|
TEST OF HETEROGENEITY
|
||||||
|---|---|---|---|---|---|---|---|
| N | OR | 95% CI | Pa | Pb | I2 (%) | ANALYSIS MODEL | |
| A allele | |||||||
| Overall | 20 | 0.96 | 0.87–1.06 | 0.44 | 0.02 | 44 | R |
| HWE studies only | 18 | 0.98 | 0.92–1.06 | 0.65 | 0.01 | 49 | R |
| Outliers off | 17 | 0.91 | 0.84–0.98 | 0.01 | 0.64 | 0 | F |
| Outliers + HWE off | 15 | 0.90 | 0.83–0.98 | 0.01 | 0.50 | 0 | F |
| Caucasian | 12 | 0.93 | 0.83–1.05 | 0.25 | 0.07 | 40 | R |
| Asian | 5 | 1.13 | 1.00–1.28 | 0.05 | 0.17 | 38 | F |
| 7–9 NOS | 13 | 0.90 | 0.83–0.98 | 0.01 | 0.35 | 9 | F |
| G allele | |||||||
| Overall | 20 | 1.05 | 0.99–1.13 | 0.12 | 0.25 | 16 | F |
| HWE studies only | 18 | 1.06 | 0.99–1.14 | 0.11 | 0.72 | 0 | F |
| Caucasian | 12 | 1.05 | 0.97–1.12 | 0.21 | 0.95 | 0 | F |
| Asian | 5 | 1.09 | 0.71–1.66 | 0.69 | 0.01 | 68 | R |
| 7–9 NOS | 13 | 1.07 | 0.99–1.15 | 0.08 | 0.82 | 0 | F |
| A/G genotype | |||||||
| Overall | 20 | 0.98 | 0.92–1.03 | 0.42 | 0.20 | 20 | F |
| HWE studies only | 18 | 0.97 | 0.91–1.03 | 0.35 | 0.27 | 16 | F |
| Caucasian | 12 | 1.01 | 0.94–1.07 | 0.87 | 0.21 | 24 | F |
| Asian | 5 | 0.88 | 0.78–1.00 | 0.05 | 0.31 | 16 | F |
| 7–9 NOS | 13 | 1.01 | 0.95–1.08 | 0.70 | 0.77 | 0 | F |
Notes: Pa: P value for test of association; Pb: P value for heterogeneity; I2 is a measure of heterogeneity expressed in %. Values in bold indicate significant associations. R: random-effects model, F: fixed-effects model.
Abbreviations: HWE, Hardy-Weinberg Equilibrium; N, number of studies; OR, odds ratio; CI, confidence interval; NOS, Newcastle-Ottawa Score.