Table 3.
Functional Annotation of RPRD1B Interacting Proteins
| Category | Term | Count | % | P value | Benjamini | FDR |
|---|---|---|---|---|---|---|
| GOTERM_BP_FAT | RNA processing | 36 | 42.9 | 1.10E−29 | 4.90E−27 | 1.60E−26 |
| GOTERM_BP_FAT | mRNA metabolic process | 30 | 35.7 | 9.70E−27 | 2.10E−24 | 1.40E−23 |
| GOTERM_BP_FAT | mRNA processing | 28 | 33.3 | 1.20E−25 | 1.80E−23 | 1.70E−22 |
| GOTERM_BP_FAT | RNA splicing | 27 | 32.1 | 1.30E−25 | 1.40E−23 | 1.80E−22 |
| GOTERM_BP_FAT | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 22 | 26.2 | 2.10E−24 | 1.80E−22 | 2.90E−21 |
| GOTERM_BP_FAT | nuclear mRNA splicing, via spliceosome | 22 | 26.2 | 2.10E−24 | 1.80E−22 | 2.90E−21 |
| GOTERM_BP_FAT | RNA splicing, via transesterification reactions | 22 | 26.2 | 2.10E−24 | 1.80E−22 | 2.90E−21 |
| GOTERM_BP_FAT | macromolecular complex assembly | 20 | 23.8 | 1.40E−09 | 1.00E−07 | 2.00E−06 |
| GOTERM_BP_FAT | macromolecular complex subunit organization | 20 | 23.8 | 4.10E−09 | 2.60E−07 | 5.80E−06 |
| GOTERM_BP_FAT | RNA elongation from RNA polymerase II promoter | 7 | 8.3 | 2.10E−07 | 1.10E−05 | 2.90E−04 |
| GOTERM_BP_FAT | mRNA cleavage | 5 | 6 | 2.50E−07 | 1.20E−05 | 3.50E−04 |
| GOTERM_BP_FAT | RNA elongation | 7 | 8.3 | 3.00E−07 | 1.30E−05 | 4.20E−04 |
| GOTERM_BP_FAT | gene silencing by RNA | 6 | 7.1 | 8.40E−07 | 3.30E−05 | 1.20E−03 |
| GOTERM_BP_FAT | chromosome organization | 14 | 16.7 | 1.70E−06 | 6.00E−05 | 2.30E−03 |
| GOTERM_BP_FAT | transcription initiation from RNA polymerase II promoter | 7 | 8.3 | 1.70E−06 | 5.60E−05 | 2.40E−03 |
| GOTERM_BP_FAT | chromatin organization | 12 | 14.3 | 5.30E−06 | 1.60E−04 | 7.40E−03 |
| GOTERM_BP_FAT | chromatin assembly or disassembly | 8 | 9.5 | 5.30E−06 | 1.50E−04 | 7.50E−03 |
| GOTERM_BP_FAT | transcription initiation | 7 | 8.3 | 5.40E−06 | 1.50E−04 | 7.70E−03 |
| GOTERM_CC_FAT | ribonucleoprotein complex | 28 | 33.3 | 2.40E−20 | 3.40E−18 | 2.90E−17 |
| GOTERM_CC_FAT | nucleoplasm | 31 | 36.9 | 2.00E−17 | 1.40E−15 | 2.30E−14 |
| GOTERM_CC_FAT | nuclear lumen | 37 | 44 | 6.90E−17 | 5.20E−15 | 1.30E−13 |
| GOTERM_CC_FAT | intracellular organelle lumen | 39 | 46.4 | 9.60E−16 | 3.50E−14 | 1.20E−12 |
| GOTERM_CC_FAT | organelle lumen | 39 | 46.4 | 2.00E−15 | 5.60E−14 | 2.40E−12 |
| GOTERM_CC_FAT | membrane-enclosed lumen | 39 | 46.4 | 4.00E−15 | 9.40E−14 | 4.70E−12 |
| GOTERM_CC_FAT | nucleoplasm part | 19 | 22.6 | 5.00E−10 | 1.00E−08 | 5.90E−07 |
| GOTERM_CC_FAT | spliceosome | 11 | 13.1 | 2.00E−09 | 3.50E−08 | 2.30E−06 |
| GOTERM_CC_FAT | DNA-directed RNA polymerase II, core complex | 6 | 7.1 | 7.60E−09 | 1.20E−07 | 9.00E−06 |
| GOTERM_CC_FAT | nuclear DNA-directed RNA polymerase complex | 6 | 7.1 | 1.90E−07 | 2.70E−06 | 2.30E−04 |
| GOTERM_CC_FAT | DNA-directed RNA polymerase complex | 6 | 7.1 | 1.90E−07 | 2.70E−06 | 2.30E−04 |
| GOTERM_CC_FAT | RNA polymerase complex | 6 | 7.1 | 2.40E−07 | 3.10E−06 | 2.80E−04 |
| GOTERM_CC_FAT | non-membrane-bounded organelle | 33 | 39.3 | 9.60E−07 | 1.10E−05 | 1.10E−03 |
| GOTERM_CC_FAT | intracellular non-membrane-bounded organelle | 33 | 39.3 | 9.60E−07 | 1.10E−05 | 1.10E−03 |
| GOTERM_CC_FAT | DNA-directed RNA polymerase II, holoenzyme | 7 | 8.3 | 4.70E−06 | 5.10E−05 | 5.50E−03 |
| GOTERM_CC_FAT | chromosome | 13 | 15.5 | 5.60E−06 | 5.60E−05 | 6.60E−03 |
| GOTERM_MF_FAT | RNA binding | 35 | 41.7 | 7.50E−24 | 9.00E−22 | 8.60E−21 |
| GOTERM_MF_FAT | purine NTP-dependent helicase activity | 9 | 10.7 | 7.10E−08 | 4.20E−06 | 8.10E−05 |
| GOTERM_MF_FAT | ATP-dependent helicase activity | 9 | 10.7 | 7.10E−08 | 4.20E−06 | 8.10E−05 |
| GOTERM_MF_FAT | helicase activity | 10 | 11.9 | 8.20E−08 | 3.30E−06 | 9.40E−05 |
| GOTERM_MF_FAT | DNA-directed RNA polymerase activity | 6 | 7.1 | 4.00E−06 | 1.20E−04 | 4.60E−03 |
| GOTERM_MF_FAT | RNA polymerase activity | 6 | 7.1 | 4.00E−06 | 1.20E−04 | 4.60E−03 |
Summarizes DAVID analysis of RPRD1B interacting proteins listed in Table 1. Gene Ontology terms of biological process (GOTERM_BP), cellular component (GOTERM_CC), and molecular function (GOTERM_MF) are shown. The column designated Count shows the number of genes in the GO term. Percent column shows the number of genes out of the total for each GO term. P-Value, Benjamini, and FDR, are statistical measures to determine confidence of gene enrichment in each GO term