Fig. 3.

Prediction of NOTCH signaling pathway members. a The differential gene expression between NOTCH on and off conditions is used to calculate the NEST E score. The NOTCH1 ChIP-seq regulatory potential score for each gene is used to calculate the NEST C score. The KEGG Notch Signaling pathway members are used as gold standard and the prediction performances of all measures are shown by ROC curves. b The area under ROC curve (AUC) is shown for each measure. The comparison between AUCs is done by Delong test