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. 2015 Oct 29;8:122. doi: 10.1186/s13045-015-0220-7

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© Lou et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — 122-Exo sensitizes HCC cells to chemotherapeutic agents. a Cell viability assay on HepG2 and Huh7 cells by combined treatment with chemotherapeutic agents and AMSC-derived exosomes. b FITC-Annexin V/PI assay in exosome-treated HCC cells after 5-FU treatment. c FC analysis for Annexin V revealed an increase in apoptotic cells in 122-Exo-treated HCC cells after 5-FU or sorafenib exposure. d, e Cell cycle analysis revealed an increase in G0/G1 population in 122-Exo-treated HepG2 cells after 5-FU or sorafenib exposure. Data are presented as means ± SE. (*p < 0.05, **p < 0.01, n = 3). U.T untreated, 122-Exo AMSC-122-derived exosomes, 67-Exo AMSC-67-derived exosomes