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A one-compartment linear disposition model was used to fit the parent drug. An additional compartment for the ODT metabolite was linked to the central compartment by its formation clearance (CLP2M). Urinary excretion of tramadol (CLPR) was estimated based on the total amount of tramadol found in urine (UR). ODT moiety-related clearance (CLM) and volume (VM) were estimated based on the ODT plasma concentrations and total ODT amount found in urine (UR); CLPO other clearance parent
