Table IV.
Evaluation of Targeted Curcumin Nanoformulations for Cancer Therapeutics
| Details of article | Description of results |
|---|---|
| Transferrin (TF)-mediated solid lipid nanoparticles (54) | TF-tagged curcumin nanoformulations show a 5-fold increased uptake by MCF-7 cancer cells. This formulation induces 44.5% apoptosis compared to curcumin nanoparticles (32.4%) at 10 μM. |
| Transferrin-targeted polymeric micelles co-loaded with curcumin and paclitaxel (55) | TF-targeted combination polymer micelles induce significant cytotoxic effect of curcumin and paclitaxel. A constant curcumin nanoformulation (5 and 10 μM) was able to reduce the paclitaxel-required IC50 concentration from ∼1.78 and 0.68 μM to ∼0.74 and 0.1 μM. |
| Anti-PSMA conjugated curcumin loaded PLGA NPs (30) | PSMA-targeted curcumin-loaded nanoparticles target only PSMA-expressing cancer cells both in vitro and in vivo. This formulation also exhibits superior anti-cancer effects against prostate cancer cells compared to native curcumin and its nanoformulation. |
| Folic acid conjugated cross-linked acrylic polymer hydrogel (56) | This curcumin nanoformulation showed higher cellular uptake in human cervical cancer cell lines than the nonfolate conjugated form. |
| Multifunctional targeting nano-carrier drug delivery system based on CD44 receptor and tumor microenvironment pH condition (57) | The anti-tumor activity of the targeted nanoformulation was most efficient in suppressing tumor growth in an animal model. |
| Magnetic core–shell nanocapsules with dual-targeting capabilities and co-delivery of multiple drugs to treat brain gliomas (58) | The combinational effects, i.e., curcumin in nanoformulation, magnetic guidance, and targeting lactoferrin receptor, have been maximal in brain tumor-bearing mice not only achieving high accumulation, but also efficiently suppressing cancer growth, either curcumin alone or in combination with doxorubicin. |
| Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein (59) | Anti-Pgp-conjugated curcumin nanoparticles exhibit superior cellular uptake by KB-V1 cells and thus enhance cytotoxicity. |
| Folate decorated dual drug loaded nanoparticle: role of curcumin in enhancing therapeutic potential of nutlin-3a (22) | Folate-targeted curcumin nanoformulations are capable of inducing enhanced expression of proapoptotic, down-regulation of anti-apoptotic proteins, and down-regulation of bcl2 and NF-κB gene/protein. |
| Surface functionalization of PLGA nanoparticles by noncovalent insertion of a homo-bifunctional spacer (60) | This novel surface-modified targeted nanoformulation internalizes more in annexin A2-positive cells than in negative cells. |
| Multistage polymeric micelles based on amphiphilic poly(β-amino ester) derivatives (61) | pH-responsive curcumin micelles are proven to have enhanced cancer growth inhibition (65.6%) ability. |
TF transferrin, PLGA poly(lactide-co-glycolide) PSMA prostate-specific membrane antigen, MCF-7 Michigan Cancer Foundation-7 breast cancer cell line, NF-κB nuclear factor kappa B, IC50 half maximal inhibitory concentration, NP nanoparticle