Figure 4.

Dry eye disease models have distinct effects on tear production. Phenol thread measurements taken at the endpoint of each DED model are expressed as a percent of baseline measurements (% Tears). Systemic saline injections or PBS injections into the extraorbital lacrimal gland did not reduce tear volumes (groups pooled as Controls; white bar; n = 19). Tear production in methyl atropine (MA) animals (gray bar; n = 10) was significantly reduced. Saporin microinjections into the extraorbital lacrimal gland did not change tear volume as compared to that in control animals (black bar; n = 8). Bars indicate mean ± SEM. *P < 0.05.