Table 3.
The relationship of NISS scores from the total score in the first 14 and 28 days of life and average daily score from NICU stay in relation to brain metrics, diffusion measures and neurobehavior prior to and after adjustment for potential confounders.
| 14 day | 14 day* | 14 day† | 28 day | 28 day* | 28 day† | Total | Total* | Total† | |
|---|---|---|---|---|---|---|---|---|---|
| Brain Metrics (n=42) | |||||||||
| BFD | −.423 .005 |
−.254 .123 |
−.252 .133 |
−.567 <.001 |
−.364 .025 |
−.367 .035 |
−.533 <.001 |
−.308 .060 |
−.347 .035 |
| BPD | −.338 .029 |
−.261 .114 |
−.273 .101 |
−.482 .001 |
−.454 .004 |
−.486 .002 |
−.385 .012 |
−.257 .119 |
−.351 .033 |
| BBPD | −.447 .003 |
−.371 .022 |
−.356 .030 |
−.615 <.001 |
−.596 <.001 |
−.585 <.001 |
−.535 <.001 |
−.418 .009 |
−.413 .011 |
| WM | −.368 .016 |
−.386 .017 |
−.398 .015 |
−.272 .081 |
−.355 .029 |
−.378 .021 |
−.150 .344 |
−.124 .458 |
−.175 .300 |
| TCD | −.245 .118 |
−.062 .713 |
.001 .997 |
−.452 .003 |
−.255 .122 |
−.173 .306 |
−.454 .003 |
−.263 .110 |
−.061 .722 |
| Diffusion Measures (n=26) | |||||||||
| Right Temporal ADC | .378 .057 |
.404 .056 |
.391 .072 |
.207 .311 |
.208 .341 |
.191 .395 |
.128 .533 |
.093 .672 |
.020 .931 |
| Left Temporal ADC | .366 .066 |
.354 .097 |
.330 .133 |
.249 .220 |
.292 .176 |
.264 .235 |
.253 .213 |
.323 .132 |
.190 .397 |
| Right Temporal RA | −.157 .445 |
−.083 .708 |
−.054 .811 |
−.352 .078 |
−.307 .155 |
−.286 .197 |
−.439 .025 |
−.417 .048 |
−.362 .097 |
| Left Temporal RA | −.320 .112 |
−.298 .167 |
−.279 .208 |
−.323 .108 |
−.186 .396 |
−.164 .466 |
−.303 .133 |
−.143 .514 |
−.057 .802 |
| Dubowitz (n=40) | |||||||||
| Total | −.307 .054 |
−.290 .086 |
−.269 .119 |
−.182 .261 |
−.042 .809 |
−.002 .990 |
−.138 .397 |
−.030 .862 |
.156 .372 |
| Reflexes | −.283 .077 |
−.416 .012 |
−.403 .016 |
−.077 .635 |
−.167 .331 |
−.140 .424 |
−.023 .886 |
−.058 .738 |
−.019 .915 |
| Abnormal Patterns | −.422 .007 |
−.358 .032 |
−.337 .047 |
−.265 .098 |
−.050 .773 |
−.003 .987 |
−.221 .170 |
−.002 .990 |
.127 .468 |
| NNNS (n=43) | |||||||||
| Nonoptimal Reflexes | .265 .086 |
.347 .030 |
.343 .035 |
.135 .389 |
.216 .187 |
.208 .209 |
.073 .641 |
.087 .597 |
.042 .800 |
*
Corrected for EGA, CRIB score, and total MRI Injury score (+age at scan for brain metrics)
BFD-bifrontal diameter; BPD-brain to brain biparietal diameter; BBPD-bone to bone biparietal diameter; WM-white matter diameter; TCD-transverse cerebellar diameter; ADC-apparent diffusion coefficient; RA-relative anisotropy