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. Author manuscript; available in PMC: 2015 Oct 30.
Published in final edited form as: Biochem Soc Trans. 2015 Apr;43(2):222–228. doi: 10.1042/BST20140272

Figure 1. Topology of the protein CLIMP-63.

Figure 1

CLIMP-63 is a type II single transmembrane protein. In the cytosol, it has an ER-anchoring sequence and a domain interacting with microtubules. In the ER lumen, CLIMP-63 has several coiled-coil domains that are required for its multimerization.