Table 2.
Genotype distribution and association analysis of CAPN10 SNP44 copy number variation genotypes with type 2 diabetes risk
| Model | Genotype | Genotype frequency (%)† | P-value | OR (95% CI) | |
|---|---|---|---|---|---|
| Control (n = 192) | Case (n = 216) | ||||
| 1 copy | |||||
| T/– | 64 (33.33) | 83 (38.42) | 0.313* | 1.23 (0.81–1.86) | |
| C/– | 8 (4.17) | 7 (3.24) | 0.732* | 0.83 (0.29–2.36) | |
| 2 copies | |||||
| Co-dominant | TT | 88 (73.33) | 99 (78.57) | 0.776 | 1 (reference) |
| TC | 29 (24.17) | 25 (19.84) | 0.77 (0.42–1.41) | ||
| CC | 3 (2.50) | 2 (1.59) | 0.59 (0.10–3.63) | ||
| Dominant | TT | 88 (73.33) | 99 (45.83) | 0.336 | 1 (reference) |
| TC + CC | 31 (25.83) | 27 (21.43) | 0.75 (0.42–1.35) | ||
| Recessive | TT + TC | 117 (97.50) | 124 (98.41) | 0.956 | 1 (reference) |
| CC | 3 (2.50) | 2 (1.59) | 0.59 (0.09–3.62) |
*P-value assessed by comparing either (T/–) or (C/–) genotype and (TT + TC + CC) genotype between cases and controls. †CAPN10 SNP44 was genotyped by denaturing high-performance liquid chromatography and real-time quantitative polymerase chain reaction. CI, confidence interval; OR, odds ratio.