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. 2015 Aug 26;19(11):2597–2606. doi: 10.1111/jcmm.12664

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Telocytes (TCs) and telopodes (Tps) are reduced in diseased human hearts. (A and B) Representative immunofluorescent confocal images showing the distribution of c-kit-positive cells (green) in a normal heart. Arrows denote TCs and arrowheads indicate TPs. (C and D) Confocal images of TCs in a patient with DCM demonstrating fewer TCs (arrows) and TPs (arrowheads) than in controls. Cardiomyocytes are stained red with Alexa633-conjugated-phalloidin. Nuclei are stained blue with 4,6-diamidino-2-phenylindole (DAPI). (E and F) Results of quantification of the number of TCs and TPs per 1 mm² myocardial area in controls and heart failure patients.