Skip to main content
. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: Clin Cancer Res. 2015 Apr 15;21(14):3347–3355. doi: 10.1158/1078-0432.CCR-15-0057

Figure 1. Increased CD8+ lymphocyte infiltration in POLE-mutant endometrial cancers.

Figure 1

(A) Results of CD8 immunohistochemistry by EC molecular subtype shown at low magnification (upper panels) and high power views of the center of the tumor (CT) and invasive margin (IM). Arrows highlight intraepithelial CD8+ cells in POLE-mutant tumor. Scale bars correspond to 500 μm in upper panel and 100 μm in the middle and lower panels. (B) Quantification of CD8+ cell number in intraepithelial and intrastromal compartments in the CT and IM by EC molecular subtype. Boxes represent the interquartile range (IQR), with upper whisker indicating the 75th percentile plus 1.5 × IQR, and the lower whisker the 25th percentile minus 1.5 × IQR. The median and mean values are indicated by a horizontal line and cross respectively. Statistical comparison between groups was made by unadjusted two-sided Mann-Whitney test, *, **, and *** correspond to P<0.05, P<0.01, and P<0.001 respectively.