Table 2.
Transcriptome Response to E2 Treatment
| GO Term | Description | n | P Value | |
|---|---|---|---|---|
| Common | GO:0006412 | Translation | 50 | 9.1E-14 |
| GO:0022411 | Cellular component disassembly | 47 | 1.6E-13 | |
| GO:0010467 | Gene expression | 209 | 1.9E-10 | |
| GO:0019438 | Aromatic compound biosynthetic process | 177 | 2.2E-09 | |
| GO:0019222 | Regulation of metabolic process | 192 | 4.6E-03 | |
| MCF7 | GO:0007049 | Cell cycle | 271 | 1.8E-40 |
| GO:0034660 | ncRNA metabolic process | 97 | 1.1E-35 | |
| GO:0050896 | Response to stimulus | 6819 | 4.2E-35 | |
| GO:0006915 | Apoptotic process | 220 | 1.2E-18 | |
| GO:0008283 | Cell proliferation | 225 | 3.4E-18 | |
| T47D | GO:0022904 | Respiratory electron transport chain | 28 | 3.7E-07 |
| GO:0045216 | Cell-cell junction organization | 46 | 5.7E-05 | |
| GO:0050896 | Response to stimulus | 837 | 8.2E-04 | |
| GO:0008219 | Cell death | 243 | 1.2E-03 | |
| GO:0007049 | Cell cycle | 207 | 7.7E-03 |
GO enrichment analysis for differentially expressed protein-coding genes, including number of genes that were regulated within each overrepresented group (n) and P value. A group was considered enriched if P < .05. Analysis performed for the common set as well as the cell line-specific sets of DE.