Table 1.
Baseline Characteristics of the Study Population, According to High-Sensitivity Cardiac Troponin T Concentration.*
| Characteristic | Troponin T <14 ng/liter (N = 1388) | Troponin T ≥14 ng/liter (N = 897) | P Value |
|---|---|---|---|
| Median age (IQR) — yr | 61 (55–68) | 64 (58–71) | <0.001 |
| Male sex — no./total no. (%) | 903/1388 (65.1) | 698/897 (77.8) | <0.001 |
| Race or ethnic group — no./total no. (%)† | 0.006 | ||
| White non-Hispanic | 926/1388 (66.7) | 571/897 (63.7) | |
| Black non-Hispanic | 218/1388 (15.7) | 170/897 (19.0) | |
| Hispanic | 164/1388 (11.8) | 127/897 (14.2) | |
| Asian non-Hispanic | 71/1388 (5.1) | 24/897 (2.7) | |
| Other non-Hispanic | 9/1388 (0.6) | 5/897 (0.6) | |
| Median body-mass index (IQR)‡ | 31.0 (27.7–34.7) | 30.9 (27.3–35.0) | 0.60 |
| Median blood pressure (IQR) — mm Hg | |||
| Systolic | 129 (118–141) | 130 (119–145) | 0.07 |
| Diastolic | 74 (68–81) | 73 (67–81) | 0.18 |
| Hypertension requiring treatment — no./total no. (%) | 1107/1371 (80.7) | 757/888 (85.2) | 0.006 |
| Hypercholesterolemia requiring treatment — no./total no. (%) | 1126/1367 (82.4) | 721/889 (81.1) | 0.45 |
| History of cigarette smoking — no./total no. (%) | 919/1388 (66.2) | 608/897 (67.8) | 0.44 |
| History of myocardial infarction — no./total no. (%) | 389/1369 (28.4) | 334/881 (37.9) | <0.001 |
| History of congestive heart failure requiring treatment — no./total no. (%) | 55/1377 (4.0) | 93/893 (10.4) | <0.001 |
| History of stroke or TIA — no./total no. (%) | 127/1388 (9.1) | 94/897 (10.5) | 0.29 |
| Median duration of diabetes mellitus (IQR) — yr | 7.2 (3.3–13.8) | 10.4 (4.9–17.9) | <0.001 |
| Chronic renal dysfunction — no./total no. (%) | 13/1385 (0.9) | 57/887 (6.4) | <0.001 |
| Median glycated hemoglobin (IQR) — % | 7.3 (6.4–8.4) | 7.4 (6.5–8.7) | 0.03 |
| Median lipids (IQR) — mg/dl | |||
| Total cholesterol | 165 (142–190) | 163 (139–194) | 0.68 |
| HDL cholesterol | 37 (32–43) | 36 (31–42) | 0.003 |
| LDL cholesterol | 93 (73–114) | 90 (72–115) | 0.30 |
| Triglycerides | 146.0 (100.0–215.0) | 151.5 (109.0–223.0) | 0.02 |
| Median estimated GFR (IQR) — ml/min/1.73 m2 | 80.3 (66.7–94.9) | 69.6 (55.1–83.3) | <0.001 |
| Median NT-proBNP (IQR) — ng/liter | 93.0 (46.4–185.8) | 280.2 (104.2–719.8) | <0.001 |
| Current medications — no./total no. (%) | |||
| Insulin | 322/1388 (23.2) | 314/897 (35.0) | <0.001 |
| Aspirin | 1234/1381 (89.4) | 771/895 (86.1) | 0.02 |
| Statin | 1036/1385 (74.8) | 666/895 (74.4) | 0.84 |
| Median myocardial jeopardy index score (IQR)§ | 41.0 (24.0–60.0) | 46.0 (28.0–65.0) | 0.001 |
| Number of lesions with ≥50% stenosis — no./total no. (%) | <0.001 | ||
| 0–1 | 470/1388 (33.9) | 216/897 (24.1) | |
| 2–3 | 581/1388 (41.9) | 366/897 (40.8) | |
| >3 | 337/1388 (24.3) | 315/897 (35.1) | |
| Number of vessels with lesions with ≥50% stenosis — no./total no. (%) | <0.001 | ||
| 1 | 574/1386 (41.4) | 284/896 (31.7) | |
| 2 | 491/1386 (35.4) | 326/896 (36.4) | |
| 3 | 321/1386 (23.2) | 286/896 (31.9) | |
| Proximal LAD stenosis of ≥50% — no./total no. (%) | 174/1388 (12.5) | 130/897 (14.5) | 0.18 |
| LVEF <50% — no./total no. (%) | 163/1388 (11.7) | 219/897 (24.4) | <0.001 |
| Any ECG abnormality — no./total no. (%) | 656/1349 (48.6) | 575/869 (66.2) | <0.001 |
| CABG revascularization stratum — no./total no. (%)¶ | 429/1388 (30.9) | 322/897 (35.9) | 0.01 |
| Assignment to prompt revascularization — no./total no. (%) | 675/1388 (48.6) | 453/897 (50.5) | 0.38 |
To convert the values for cholesterol to millimoles per liter, multiply by 0.02586. To convert the values for triglycerides to millimoles per liter, multiply by 0.01129. CABG denotes coronary-artery bypass grafting, ECG electrocardiogram, GFR glomerular filtration rate, HDL high-density lipoprotein, IQR interquartile range, LAD left anterior descending coronary artery, LDL low-density lipoprotein, LVEF left ventricular ejection fraction, NT-proBNP N-terminal pro–brain natriuretic peptide, and TIA transient ischemic attack.
Race or ethnic group was self-reported.
The body-mass index is the weight in kilograms divided by the square of the height in meters.
The myocardial jeopardy index is the proportion (0 to 100%) of the myocardium supplied by significantly diseased coronary arteries. Thus, a higher score represents more severe coronary artery disease and is associated with worse prognosis.
In the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes trial, before randomization, patients were stratified according to the most appropriate method of coronary revascularization (percutaneous coronary intervention vs. CABG).