Table 1. Mtb growth inhibitory activities of BAS 00623753 and a small set of analogs.
Molecule structures are in S1 Data.
| Compound # | Ar | R | Mtb MIC (H37Rv) μg/mL |
|---|---|---|---|
| JSF-2210 = synthetic BAS00623753 | 2-NO2Ph | CH2(2-pyridyl) | >50 |
| JSF-2133 | Ph | CH2(2-pyridyl) | >50 |
| JSF-2170 | 2-NO2Ph | (CH2)2(2-pyridyl) | >50 |
| JSF-2171 | 2-NO2Ph | CH2(2-pyrazinyl) | >50 |
| JSF-2172 | 2-NO2Ph | CH2(2-(3 Mepyridyl)) | >50 |
| JSF-2173 | 2-NO2Ph | CH2(2-(4-Mepyridyl)) | >50 |
| JSF-2174 | 2-NO2Ph | CH2(2-(5-Clpyridyl)) | >50 |
| JSF-2175 | 2-NO2Ph | CH2(2-(5-Mepyridyl)) | >50 |
| JSF-2177 | 2-NO2Ph | CH2(4-pyrimidinyl) | >50 |
| JSF-2178 | 2-NO2Ph | CH2(2-pyrimidinyl) | >50 |
| JSF-2176 | 2-NO2Ph | CMe2(2-pyrimidinyl) | >50 |
| JSF-2208 | 2-FPh | CH2(2-pyridyl) | >50 |
| JSF-2209 | 2-MePh | CH2(2-pyridyl) | >50 |
| JSF-2211 | 2-CF3Ph | CH2(2-pyridyl) | >50 |