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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Cell Physiol. 2016 Jan;231(1):50–61. doi: 10.1002/jcp.25067

Table 5.

Clinical studies of periodontal regeneration using stem cell-based regenerative approaches.

Reference Type of Study Cell type (Cell Source) Defect type Carrier Significance
(Yamada et al., 2006) Case Report (n=1) Autologous BMSSCs (from iliac crest) Angular interproximal defect PRP Highest PPD reduction and CAL gain were both 4mm after 1 year.
(Yamada et al., 2013) Case Series (n=17) Autologous BMSSCs (from iliac crest) Angular interproximal defect PRP The treatment resulted in mean PPD reduction of 5.12± 2.45 mm, CAL gain of 4.29 ± 1.32 mm, and radiographic bone height gain of 3.12 ± 1.23. No side effects were observed.
(Feng et al., 2010) Case series (n=3) Autologous PDLPs and PDLSCs (from extracted 3rd Molars) Intrabony