Table 1. In vitro anti-leishmanial activity and cytotoxicity results for trans-Resveratrol Analogs.
| IC50 | IC50 | CC50 | ||
|---|---|---|---|---|
| Drug | Promastigotes | Intracellular Amastigotes | Peritoneal Macrophages | SI * |
| Pterostilbene | 17.7 μM | 33.2 μM | 181.0 μM | 5.4 |
| Piceatannol | 65.0 μM | 45.0 μM | >400.0 μM | >8.9 |
| Polydatin | 95.5 μM | 29.0 μM | 150.0 μM | 5.2 |
| Oxyresveratrol | 65.0 μM | 30.5 μM | 128.0 μM | 4.2 |
| Amphotericin B | 0.1 μM | 8.8 nM | >5.0 μM | n.d. |
* The selectivity index (SI) was calculated as the ratio of CC50 on murine peritoneal macrophages to IC50 on L. amazonensis intracellular amastigotes.
n.d.–not determined.