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. 2015 Oct 30;10(10):e0141597. doi: 10.1371/journal.pone.0141597

Table 2. The 22 signature genes that are specifically expressed in both RPE in mouse and in human.

Gene Symbol Genbank ID Mus Musculus Genbank Homo Sapiens
ADORA2B NM_007413 NM_000676
G-protein coupled adenosine receptor. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine.
BMP4 NM_007554 NM_001202
A member of the bone morphogenic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors.
CA14 NM_011797 NM_012113
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydratyion of carbon dioxide.
CSPG5 NM_001166273 NM_001206942.1 
A proteoglycan that may function as a neural growth and differentiation factor.
CTSD NM_009983 NM_001909.4
An aspartic protease resident in endosomal and lysosomal compartments of all eukaryotic cells.
GPAM ENSMUST00000086868  
A mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids.
ITGB8 NM_177290 NM_002214.2
Cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells.
KRT18 NM_010664 NM_000224
Keratin 18 is a type I cytokeratin (this type constitutes the type I intermediate filaments of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells), together with Krt8 is the most common found product of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body.
RDH10 NM_133832 [NM_172037
A retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor.
RGR ENSMUST00000022338 NM_002921
A putative retinal G-protein coupled receptor and acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal.
RLBP1 NM_020599 NM_000326
Retinaldehyde binding protein 1. carries 11-cis-retinaldehyde or 11-cis-retinal as physiological ligands. It may be a functional component of the visual cycle.
SEMA3C NM_013657 NM_006379.3
Binds to plexin family members and plays an important role in the regulation of developmental processes.
SLC16A8 [MCT3] NM_020516 NM_013356
Belongs to a family of monocarboxylate transporters. It is expressed in the basolateral membrane of the RPE.
SLC39A12 NM_001012305 NM_152725
Zinc transporter, which is a cofactor for hundreds of enzymes and therefore normal cell function.
SLC6A13 NM_144512 NM_016615
Encodes a sodium- and chloride-dependent GABA transporter [GAT2]
SLC6A20 NM_139142 NM_020208
Encodes an amino acid transmembrane transporter that mediates the transport of small hydrophilic substances across cell membranes.
SLC7A10 NM_017394 NM_019849
Encodes an amino acid transmembrane transporter that mediates high-affinity transport of D-serine and several other neutral amino acids.
SPOCK1 NM_009262 NM_004598
Encodes he protein core of a seminal plasma proteoglycan containing chondroitin- and heparin-sulfate chains.
SULF1 NM_172294 NM_015170
Enzyme which can modulate the activity if heparan sulfate, thereby influencing the regulation of cell growth, proliferation, differentiation and migration.
TMEM27 NM_020626 NM_020665
binds to amino acid transporters and regulates their expression on the plasma membrane
TMEM56 NM_178936 NM_152487
function unknown  
TRPM3 NM_001035246 NM_206948
Belongs to the family of transient receptor potential channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis.

Derived from a comparison between our “Mouse RPE signature genes” dataset (this study) and two (modified) studies on the human RPE transcriptome [12,15]. We show the gene symbol, genbank ID for both species and the GO annotation of each gene.