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. 2015 Oct 30;10(10):e0141597. doi: 10.1371/journal.pone.0141597

Table 4. Overview of significant canonical pathways assigned by the Ingenuity knowledge database to the 101 genes that are the result of comparing the “Mouse high RPE gene expression” and the “Human very low RPE gene expression” datasets.

Endocrine Signaling & Metabolic Function
Ephrin Receptor Signaling
PEDF Signaling
Protein Kinase A Signaling
Gαq Signaling
FGF Signaling
Phospholipase C Signaling
NGF Signaling
GNRH Signaling
PXR/RXR Activation
Ephrin B Signaling
Immunological Function
iCOS-iCOSL Signaling in T Helper Cells
Role of NFAT in Regulation of the Immune Response
Dendritic Cell Maturation
B Cell Receptor Signaling
IL-8 Signaling
Thrombin Signaling
PKCθ Signaling in T Lymphocytes
CD28 Signaling in T Helper Cells
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
GM-CSF Signaling
PI3K Signaling in B Lymphocytes
Basic pathways of cellular (dys)function
Prostate Cancer Signaling
Regulation of the Epithelial-Mesenchymal Transition Pathway
Wnt/Ca+ pathway
P2Y Purigenic Receptor Signaling Pathway
Estrogen-Dependent Breast Cancer Signaling
Colorectal Cancer Metastasis Signaling
Epithelial junctions
Tight Junction Signaling
Epithelial Adherens Junction Signaling
Vesicle mediated transport
Clathrin-mediated Endocytosis Signaling
Oxidative stress
Hypoxia Signaling in the Cardiovascular System