Table 1. Blood and urinary chemistry in control, meloxicam or ibuprofen treated rats on day 14.
| Control (n = 11) | Meloxicam (n = 12) | Ibuprofen (n = 12) | |
|---|---|---|---|
| Original Body weight, g | 183.3 ± 2.8 | 192.3 ± 6.3 | 193.0 ± 6.3 |
| Final Body weight, g | 255.5 ± 2.4 | 299.8 ± 6.4* | 302.5 ± 6.4* |
| Urine output, ml per 24 h | 15.0 ± 2.1 | 33.7 ± 5.1* | 32.8 ± 3.2* |
| Urine osmolality, mOsm/kg H2O | 1421 ± 319 | 475 ± 81* | 578 ± 121* |
| Urinary Na, mM | 101.8 ± 5.3 | 100.9 ± 10.7 | 108.3 ± 21.7 |
| Urinary K, mM | 174.3 ± 8.5 | 157.4 ± 17.1 | 208.5 ± 42.3 |
| Urinary Cl, mM | 126.2 ± 8.9 | 105.7 ± 14.1 | 142.1 ± 35.4 |
| Urinary creatinine, mM | 3.1 ± 0.9 | 3.4 ± 1.0 | 2.6 ± 0.9 |
| Urinary excretion of Na, mmol/kg/day | 8.2 ± 0.6 | 10.6 ± 1.9 | 15.3 ± 4.7 |
| Urinary excretion of K, mmol/kg/day | 14.0 ± 1.0 | 14.7 ± 1.8 | 29.4 ± 9.1 |
| Urinary excretion of Cl, mmol/kg/day | 10.1 ± 1.1 | 9.5 ± 1.4 | 20.2 ± 7.8 |
| Urinary excretion of urea, mmol/kg/day | 24.1 ± 0.6 | 30.5 ± 1.7* | 35.1 ± 3.2* |
| Urinary excretion of creatinine, mmol/kg/day | 0.33 ± 0.05 | 0.36 ± 0.1 | 0.34 ±0.1 |
| Creatinine clearance, ml/min | 0.22 ± 0.05 | 0.26 ± 0.08 | 0.25 ± 0.07 |
| Plasma urea, mM** | 7.3 ± 0.2 | 7.3 ± 0.2 | 7.7 ± 0.7 |
| Plasma creatinine, μM** | 288.1± 16.7 | 286 ± 15.7 | 265 ± 13.8 |
| Urine PGE2, μM | 6.1 ±1.8 | 3.1 ± 1.1 | 1.3 ± 0.2* |
| Plasma vasopressin, pg/ml** | 0.60 ± 0.06 | 0.70 ± 0.04 | 0.70 ± 0.04 |
Data are presented as mean ± SEM,
*P<0.05 compared with control rats,
**n = 6 for plasma measurements