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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Ann N Y Acad Sci. 2015 Apr 30;1362(1):98–109. doi: 10.1111/nyas.12760

Figure 4. Ag-specific B cell responses to TNP-Ficoll are similar between mice and non-human primates (NHP).

Figure 4

A) Ag-specific B cells (upper panels) and their CD11b expression levels (lower panels) in mice and AGM prior to and 5 days following TNP-Ficoll immunization. B220 and CD19 were used to identify splenic mouse B cells and CD20 and CD19 were used to identify primate blood B cells. Representative CD11b+ Ag-specific B cell frequencies before and following (d5) immunization are indicated. B) CD19, CD21, PD-1, and CD86 expression levels by gated Ag-specific B cells on d0 (thin line) and 5 days post immunization (thick line). Shaded histograms indicate expression by non-Ag-specific B cells in immune animals. Dotted lines indicate isotype control staining for Ag-specific B cells. Adapted from Yammani and Haas52 and Haas12.