Table 2.
Morphometric measure at sacrifice
| Early | Late | |||||||
|---|---|---|---|---|---|---|---|---|
| Sham (n = 8) | AR + SIL (n = 8) | AR (n = 7) | p value (disease) | p value (treatment) | AR + SIL (n = 6) | AR (n = 5) | p value (treatment) | |
| Body weight, g | 670 ± 18 | 627 ± 13 | 711 ± 28 | 0.23 | 0.01* | 657 ± 28 | 731 ± 53 | 0.23 |
| Heart weight, g | 1.66 ± 0.07 | 2.07 ± 0.13 | 2.45 ± 0.16 | <0.05* | 0.08 | 2.00 ± 0.11 | 2.27 ± 0.25 | 0.30 |
| Heart weight ratio*, mg | 2.49 ± 0.12 | 3.30 ± 0.17 | 3.47 ± 0.23 | <0.01* | 0.57 | 3.06 ± 0.21 | 3.08 ± 0.18 | 0.94 |
| LV weight, g | 1.24 ± 0.08 | 1.51 ± 0.09 | 1.76 ± 0.13 | 0.01* | 0.13 | 1.49 ± 0.09 | 1.65 ± 0.17 | 0.40 |
| RV weight, g | 0.26 ± 0.01 | 0.30 ± 0.02 | 0.36 ± 0.03 | <0.05* | 0.14 | 0.31 ± 0.03 | 0.36 ± 0.04 | 0.34 |
| Lung weight, g | 1.59 ± 0.03 | 1.73 ± 0.04 | 2.10 ± 0.36 | 0.11 | 0.34 | 1.69 ± 0.07 | 1.72 ± 0.11 | 0.86 |
Comparison of morphometric measures at sacrifice between sham and AR (disease p value) and between AR and AR+SIL (treatment p value). Left ventricle (LV) and right ventricle (RV)
* p value < 0.05