Table 3.
Invasive hemodynamic measurements
| Baseline | Sacrifice | ||||||
|---|---|---|---|---|---|---|---|
| Sham (n = 8) | AR (n = 8) | AR + SIL (n = 8) | Sham (n = 6) | AR (n = 4) | AR + SIL (n = 4) | p value | |
| (A) Early treatment group | |||||||
| HR | 318 ± 14 | 316 ± 8 | 324 ± 18 | 355 ± 11 | 324 ± 8 | 333 ± 15 | 0.97 |
| Systolic BP | 133 ± 7 | 134 ± 6 | 134 ± 11 | 140 ± 4 | 140 ± 10 | 131 ± 8 | 1.00 |
| Diastolic BP | 90 ± 4 | 91 ± 4 | 98 ± 5 | 92 ± 2 | 78 ± 7 | 78 ± 2 | 0.57 |
| PP | 42 ± 10 | 46 ± 10 | 35 ± 11 | 47 ± 6 | 62 ± 7 | 53 ± 7 | 1.00 |
| dp/dtmax | 8243 ± 280 | 8841 ± 220 | 8645 ± 301 | 8150 ± 204 | 7440 ± 317 | 7864 ± 290 | 0.96 |
| dp/dtmin (−) | 6960 ± 318 | 7620 ± 240 | 7944 ± 421 | 7165 ± 461 | 5446 ± 432 | 5904 ± 617 | 1.00 |
| LVESP | 131 ± 10 | 137 ± 8 | 131 ± 11 | 129 ± 9 | 125 ± 12 | 126 ± 13 | 0.26 |
| LVEDP | 9.1 ± 1.3 | 8.1 ± 2.0 | 8.3 ± 1.2 | 8.1 ± 1.9 | 5.7 ± 2.4 | 9.8 ± 4.6 | 0.96 |
| Tau | 12.4 ± 0.7 | 12.4 ± 0.7 | 12.1 ± 0.6 | 13.8 ± 1.1 | 11.1 ± 2.1 | 13.3 ± 2.6 | 0.81 |
| Baseline | Sacrifice | ||||||
|---|---|---|---|---|---|---|---|
| AR (n = 5) | AR + SIL (n = 6) | AR (n = 5) | AR + SIL (n = 6) | p value | |||
| (B) Late treatment group | |||||||
| HR | 296 ± 12 | 269 ± 12 | 235 ± 6 | 267 ± 10 | 0.02* | ||
| Systolic BP | 117 ± 3 | 115 ± 4 | 131 ± 6 | 128 ± 3 | 0.98 | ||
| Diastolic BP | 85 ± 2 | 82 ± 3 | 65 ± 3 | 82 ± 2 | 0.03* | ||
| PP | 31 ± 2 | 33 ± 2 | 66 ± 7 | 46 ± 4 | 0.05* | ||
| dp/dtmax | 7600 ± 225 | 7810 ± 339 | 6473 ± 386 | 8211 ± 203 | 0.44 | ||
| dp/dtmin (−) | 6836 ± 552 | 6893 ± 499 | 7120 ± 1474 | 6443 ± 556 | 0.25 | ||
| LVESP | 104 ± 10 | 110 ± 7 | 148 ± 4 | 125 ± 9 | 0.29 | ||
| LVEDP | 4.9 ± 0.4 | 4.4 ± 1.0 | 7.2 ± 0.5 | 8.5 ± 2.9 | 0.35 | ||
| Tau | 10.2 ± 0.7 | 10.1 ± 0.3 | 18.2 ± 1.5 | 10.6 ± 0.3 | 0.03* | ||
Early treated groups (panel A) and late treated groups (panel B) at baseline (left) and at sacrifice (right). p values are from paired analysis between AR and AR+SIL