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Empirical bayes estimates (black dots) and population mean estimates (black lines) of midazolam clearance (a) and oral bioavailability (b) of the final pharmacokinetic model in 20 morbidly obese patients (black closed dots) and 18 bariatric patients (black open dots) versus body weight (kg). Parameter values found for healthy volunteers studies from the literature were added for comparison (grey dots) (25,34–40).
