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Temperature- (a) and time- (b) dependent Dox release kinetics from RGD-TSL and TSL. Temperature-dependent drug release profile was performed in temperatures between 37 and 45°C for 5 min in 90% FCS. Time-dependent release was carried for 1 h at 42°C in 99,7% FCS. Mean of three independent experiments with three different batches of liposomes. TEM-cryo imaging (c) of Dox-TSL and Dox-RGD-TSL. Bar, 100 nm.
