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Female ApoE4/3xTg mice showed more prominent AD pathology in the hippocampus. Representative image of dot plot on Aβ levels in hippocampus of nonTg, 3xTg and ApoE4/3xTg mice (upper). The optical density of dot plot was presented in the graph (lower). Female ApoE4/3xTg mice demonstrated a significant increase of Aβ (∗p < 0.001 vs. nonTg, #p < 0.01 vs. 3xTg, †p < 0.05 vs. male). N = 4 per group. Data is presented as Mean ± SEM. Two-way ANOVA for genotype and sex differences.
