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. 2015 Oct 31;6:1220. doi: 10.3389/fmicb.2015.01220

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Copyright © 2015 Matsunaga, Masaoka, Sawasaki, Morishita, Iwatani, Tatsumi, Endo, Yamamoto, Sugiura and Ryo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dose-response curve of HIV-1 PR activity in the presence of PIs, as determined by CFDSA. WT HIV-1 PR or a drug-resistant PR (PR02-A, as shown in Figure 3) harboring L10I/G48S/I54V/V82F/L90M mutations was tested in the presence of the indicated concentration of PIs by CFDSA. Luminescent AlphaScreen signals were plotted for each PI, and IC₅₀ values were calculated using XLfit for each inhibitor. Fold resistance value (FRV) was calculated using the IC₅₀ value of the drug-resistant PR divided by the IC₅₀ value of the WT PR. NC, negative control (DHFR).