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. 2015 Oct 30;15:223. doi: 10.1186/s12883-015-0481-3

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© Sambuughin et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Pedigree of the Siberian family with Hereditary spastic paraplegia. Filled symbols indicate individuals affected with HSP; open symbols represent unaffected family members. The p.R719W mutation was identified in the affected family members II:6, III:2, III:3, III:7, IV:1, but the test for the mutation was negative in unaffected individuals III:1, IV:2, IV:3, IV:4