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. 2015 Oct 30;15:223. doi: 10.1186/s12883-015-0481-3

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© Sambuughin et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Results of functional analysis of the c.2155C > T, p.R719W mutation. a HeLa cells transiently transfected with vectors containing the wild-type (upper panel) and mutant (bottom panel) DNM2. The p.R719W mutant exhibits punctate pattern of DNM2 expression (arrowheads), whereas cells transfected with wild type DNM2 show diffuse staining of the cytoplasm. Uptake of transferrin is reduced in cells expressing mutant DNM2 (arrows). Transferrin is labeled by Alexa-Flour 488 (green); nuclei are labeled with blue stain. b Quantification of transferrin uptake. The histogram represents the mean +/− standard error of the corrected total transferrin fluorescence of WT (n = 30 cells) and p.R719W (n = 25 cells); P < 0.001