Table 2.
Baseline demographics, biomarkers and echocardiographic parameters of patients with and without diastolic dysfunctiona
| Normal (n = 100) | Diastolic dysfunction (n = 218) | F | p-value | |
|---|---|---|---|---|
| Age (years) | 50.82 ± 9.34 | 54.83 ± 9.8 | 11.85 | 0.001 |
| Male | 60 (60 %) | 141 (64.7 %) | - | 0.453 |
| PCF (ml) | 67.32 ± 31.95 | 86.79 ± 31.77 | 25.68 | <0.001 |
| TPAF (ml) | 6.32 ± 3.73 | 8.63 ± 4.61 | 19.24 | <0.001 |
| BMI (kg/m2) | 25.05 ± 3.78 | 25.36 ± 4.14 | 0.415 | 0.52 |
| HbA1c (%) | 4.84 ± 2.44 | 4.84 ± 2.48 | <0.001 | 0.992 |
| Cholesterol (mg/dL) | 195.77 ± 45.85 | 203.94 ± 42.61 | 2.399 | 0.122 |
| LDL (mg/dL) | 124.72 ± 42.02 | 124.98 ± 46.85 | 0.002 | 0.963 |
| Hs-CRP (mg/dL) | 0.116 ± 0.039 | 0.166 ± 0.034 | 1.323 | 0.251 |
| BNP (pg/mL) | 21.03 ± 4.91 | 35.16 ± 6.7 | 3.572 | 0.06 |
| Hypertension | 29 (29 %) | 73 (33.5 %) | - | 0.441 |
| Diabetes | 12 (12 %) | 34 (15.6 %) | - | 0.493 |
| Hyperlipidemia | 40 (40 %) | 69 (31.7 %) | - | 0.162 |
| LAD (mm) | 28.76 ± 6.59 | 31.22 ± 6.08 | 10.64 | 0.001 |
| E (cm/s) | 68.81 ± 15.22 | 62.24 ± 16.23 | 11.7 | 0.001 |
| DT (ms) | 199.95 ± 35.88 | 210.04 ± 45.27 | 3.85 | 0.045 |
| IVRT (ms) | 85.66 ± 13.66 | 92.41 ± 15.49 | 13.98 | <0.001 |
| E’ (cm/s) | 10 ± 1.59 | 6.7 ± 1.42 | 344.91 | <0.001 |
| E/E’ | 7.04 ± 1.85 | 9.63 ± 3.09 | 60.51 | <0.001 |
| Dias-D (ms) | 22.62 ± 18.2 | 30.42 ± 21.66 | 9.793 | 0.002 |
Data are presented as mean ± standard deviation or number (percentage)
aDiastolic dysfunction was determined according to EAE/ASE recommendations [19]
Abbreviations same as Table 1