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. 2015 Oct 31;6:210. doi: 10.1186/s13287-015-0200-4

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© Cao et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Aspirin stimulates the osteogenesis of BMSC in vitro and in vivo. BMSC treated with different concentrations of aspirin increased the capability of forming Alizarin red-positive calcified deposits a. BMSC treated with 75 μg/ml aspirin showed the up-regulation of bone related genes (Runx2 and osteopontin) b. Aspirin treatment significantly stimulated BMSC-mediated bone formation in immunocompromised mice transplants c-e. The results are representative of at least three independent experiments. Results are expressed as mean ± standard deviation (SD) and statistical significance is shown as (*) p < 0.05 or (**) p < 0.01. Scale bars = 100 μm. B bone, HA hydroxyapatite/tricalcium phosphate, CT connective tissues, BMSC bone marrow mesenchymal stem cells