. 2015 May 28;88(1051):20140829. doi: 10.1259/bjr.20140829

Table 2.

Dose vs exposure time to achieve a prescribed biologically weighted dose of 60 Gy in the tumour (T) and balloon adjacent tumour bed tissue (TB) and normal tissue (N), with 72 µg of californium mass

Therapy ²⁵²Cf plus	Time (h)	Dose (Gy) (relative biological effectiveness)
		T	TB	I₁	I₂	N^a
		0.25^b	2.15	2.65	6.85
		BNCT^c	1.0	60^d	6.5	1.6	0.5	2.4
BNCT^c HWB	54.0	^e	60	91.5	30.0	20.7
BNCT^c LWB	68.2	^e	60	126.8	19.3	23.0

BNCT, boron neutron capture therapy; Cf, californium-252 brachytherapy; HWB, balloon catheter filled with heavy water; LWD, balloon catheter filled with light water.

^{^a}

Higher dose at normal tissue at a relative distance referent to 1.65 cm depth (surface balloon) in case of HWB and LWB, and 5.85 cm right to Cf-BNCT.

^{^b}

Relative distance between the centre of the Cf source and the voxel position in which the dose was evaluated, in centimetres.

^{^c}

Boron concentrations of 52.5 µg g⁻¹ in the tumour and infiltrations, and 15 µg g⁻¹ in the adjacent normal tissue (concentration ratio of 1:3.5).

^{^d}

Value taken at a voxel near the surface of the californium-252 source placed at a non-resectable tumour represented on the model.

^{^e}

Resected tumour; volume filled with moderator balloon.