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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Pediatr Res. 2015 Aug 3;78(5):547–553. doi: 10.1038/pr.2015.137

Figure 3.

Figure 3

Receiver-operator characteristic curves for Random Forest models of the diagnostic performance of biomarkers derived and validated in Cohorts 1 and 2. A). Performance of 16 biomarkers derived from Cohort 1 and validated on Cohort 2 (red curve; AUC 0.84); performance of commonly available biomarkers (ANC, ESR, concentration of A1AT, CRP, and fibrinogen, and platelet count) validated on Cohort 2 (green curve; AUC 0.91); performance of extended set of clinically available biomarkers (commonly available biomarkers from green curve plus ALT and GGT) validated on Cohort 2 (blue curve; AUC 0.92) B). Performance of 11 biomarkers derived from Cohort 2 and validated on Cohort 1(red curve; AUC 0.93); performance of commonly available biomarkers validated on Cohort 1 (green curve; AUC 0.94); performance of extended set of clinically available biomarkers (commonly available biomarkers from green curve plus ALT and GGT) validated on Cohort 1 (blue curve; AUC 0.96).