Table 3.

Correlation between estrogen receptor (ER)β and clinicopathologic parameters in patients with pancreatic neuroendocrine tumors

Characteristics (%)	ERβ Category			p value
	Negative (n=5)	Low (n=87)	High (n=39)
Median age (range)	56 y (49–63)	54 y (22–79)	60 y (18–76)	0.41
Median size (range)	5.0 cm (2.0 – 8.0)	4.0 cm (1.1 – 15.0)	2.6 (0.7 – 20.0)	0.02
Functionality				0.23
Non-functional	4 (4)	76 (70)	29 (26)
Insulinoma	0 (0)	7 (50)	7 (50)
Non-insulinoma	1 (13)	4 (50)	3 (37)
MEN1	1 (9)	5 (45)	5 (45)	0.26
WHO grade				0.02
Low (G1)	5 (7)	41 (57)	26 (36)
Intermediate (G2)	0 (0)	46 (78)	13 (22)
AJCC Stage				0.006
I-IIA	1 (2)	34 (55)	26 (43)
IIB	3 (9)	21 (64)	9 (27)
IV	1 (3)	32 (86)	4 (11)

Abbreviations: WHO, World Health Organization; AJCC, American Joint Committee on Cancer