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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Pancreas. 2014 Oct;43(7):996–1002. doi: 10.1097/MPA.0000000000000203

Table 4.

Correlation between estrogen-induced genes and ERβ immunohistochemistry in pancreatic neuroendocrine tumors

Characteristics N Median Estrogen-Induced Genes (mRNA/18S rRNA) ×104 (range)
PR EIG121 IGF-1 IGF-1R sFRP1 sFRP4
ERβ Allred score (ρ) 131 0.39 0.30 −0.14 0.17 −0.14 −0.10
  P value <0.001 <0.001 0.10 0.05 0.11 0.28
ERβ Category*
  Negative 5 17 (4.9 – 38) 230 (71 – 640) 1.9 (1.0 – 23) 16 (9.6 – 74) 7.9 (1.0 – 16) 34 (2.0 – 320)
  Low 87 23 (0 – 450) 350 (9.4 – 1800) 1.6 (0 – 14) 17 (0 – 130) 6.6 (0.2 – 210) 22 (0.1 – 540)
  High 39 57 (12 – 540) 490 (79 – 1700) 1.2 (0.1 – 11) 32 (2.6 – 230) 4.0 (0.3 – 106) 17 (0.2 – 280)
  P value <0.001 0.02 0.27 0.06 0.30 0.39
*

ERβ category: negative = Allred scrore 0, low = Allred score 3–6, high = Allred score 7–9.

Abbreviations: ER, estrogen receptor; PR, progesterone receptor; EIG121, estrogen-induced gene – 121; IGF, insulin-like growth factor; IGF-1R, insulin-like growth factor-1 receptor; sFRP, secreted frizzled-related protein; ρ, Spearman correlation coefficient.