Fig. 2.

Overview of the molecular mechanisms underlying regulation of signaling pathways by methylation modifiers. Methylation modifiers can modulate signaling pathways by (i) methylating and demethylating receptor kinases (A), effectors (e.g., kinases) (B), and activators/repressors of effectors (B); (ii) transcriptionally regulating expression of components in signaling pathways (C); and (iii) controlling the activities of signaling components via physical interaction (D). KDM lysine demethylases, KMT lysine methyltransferases, Me methylation