Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Methylation modifiers and MAPK signaling pathways. The lysine demethylase KDM2A activates ERK signaling by repressing expression of the ERK phosphatase DUSP3, while the lysine methyltransferase SMYD3 activates MAPK signaling through methylation of MAP3K2. PRMT5 methylates EGFR and RAF1 to downregulate MAPK signaling
