Table II. Evaluation of anti-Pfs25 antibody titers in mice immunized with CHrPfs25.
(a) CHrPfs25 adsorbed to alum and vaccinated via IP and IM routes | |||
---|---|---|---|
Antibody titers | |||
Groups | Prime (Day 21) | 1st Boost (Day 31) | 2nd Boost (Day 52) |
IP | 0 | 320,000 | 640,000 |
IM | 800 | 320,000 | 640,000 |
(b) CHrPfs25 admixed with NE and PGA-NPs administered via IM route | |||
Antibody titers | |||
Groups | Prime (Day 21) | 1st Boost (Day 31) | 2nd Boost (Day 52) |
8% NE | 400 | 160,000 | 320,000 |
4% NE | 800 | 320,000 | 640,000 |
4% NE+MPL-A | 400 | 80,000 | 640,000 |
4% NE+Chitosan | 0 | 20,000 | 640,000 |
PLGA-NP (20 mg/mL) | 800 | 80,000 | 320,000 |
PLGA-NP (10 mg/mL) | 800 | 20,000 | 160,000 |