Table 1. HLA-B types and BD-associated amino acids.
HLA-type | Amino acid |
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pos. | 9 | 12 | 24 | 41 | 45 | 63 | 67 | 77 | 80 | 95 | 97 | 103 | 116 | 152 | 163 | 171 | |
HLA-B*15 | Tyr | Met | Ala | Ala | Met | Glu† | Ser† | Ser† | Asn† | Leu† | Arg† | Val | Ser | Glu | Leu | Tyr† | |
HLA-B*27 | His† | Val† | Thr† | Ala | Glu | Glu† | Cys | Asp | Thr | Leu† | Asn | Val | Asp | Val† | Glu | Tyr† | |
HLA-B*49† | His† | Met | Thr† | Thr† | Lys† | Glu† | Ser† | Asn | Ile | Trp | Arg† | Leu† | Leu‡ | Glu | Leu | Tyr† | |
HLA-B*51 | Tyr | Met | Ala | Ala | Thr | Asn | Phe | Asn | Ile | Trp | Thr | Val | Tyr | Glu | Leu | His | |
HLA-B*57 | Tyr | Met | Ala | Ala | Met | Glu† | Met | Asn | Ile | Ile | Val | Val | Ser | Val† | Leu | Tyr† |
Bold indicates the amino acids with genome-wide significant association (P < 5 × 10−8) with disease; protective HLA types and amino acids marked with †.
Protective amino acid with significant association after conditioning on positions 97, 152, and 67 [43].