Table 1. HLA-B types and BD-associated amino acids.

HLA-type	Amino acid
	Pos.	9	12	24	41	45	63	67	77	80	95	97	103	116	152	163	171
HLA-B*15		Tyr	Met	Ala	Ala	Met	Glu†	Ser†	Ser†	Asn†	Leu†	Arg†	Val	Ser	Glu	Leu	Tyr†
HLA-B*27		His†	Val†	Thr†	Ala	Glu	Glu†	Cys	Asp	Thr	Leu†	Asn	Val	Asp	Val†	Glu	Tyr†
HLA-B*49†		His†	Met	Thr†	Thr†	Lys†	Glu†	Ser†	Asn	Ile	Trp	Arg†	Leu†	Leu‡	Glu	Leu	Tyr†
HLA-B*51		Tyr	Met	Ala	Ala	Thr	Asn	Phe	Asn	Ile	Trp	Thr	Val	Tyr	Glu	Leu	His
HLA-B*57		Tyr	Met	Ala	Ala	Met	Glu†	Met	Asn	Ile	Ile	Val	Val	Ser	Val†	Leu	Tyr†

Bold indicates the amino acids with genome-wide significant association (P < 5 × 10⁻⁸) with disease; protective HLA types and amino acids marked with †.

^‡Protective amino acid with significant association after conditioning on positions 97, 152, and 67 [43].