Figure 3.

Effect of particle physicochemical properties on interstitial transport. A.) Interstitial fluid pressure is often uniformly elevated rendering diffusion the main mechanism of interstitial transport within the pores of the collagen network in the tumor interstitial space (adapted with permission from ⁸⁵). B.) Size-dependent interstitial diffusivity as a function of the hydrodynamic radius for diffusion in PBS, the dorsal skin and the brain (with permission from ⁸³). C.) Simulation results for the effect of electrostatic repulsion on interstitial diffusivity. Normalized diffusion is the ratio of the diffusion coefficient in the tissue over the diffusion coefficient in water and λ is the ratio of particle radius divided by the fiber radius (with permission from ⁶⁹). D.) Effect of particle shape on the interstitial transport of nanoparticles. Intratumor distribution refers to the area of tumor sections occupied by the particles and the distribution of the spherical and rod-like particles in a tumor section (Bottom). Asterisk denotes a statistically significant difference (with permission from ⁵⁵).