Skip to main content
. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Nanomedicine. 2015 Aug 15;11(8):1893–1907. doi: 10.1016/j.nano.2015.07.015

Figure 4.

Figure 4

Effect of binding affinity and drug release rate on the efficacy of two-stage and multistage drug delivery systems. A.) Conventional, two-stage delivery systems are composed of the nano-carrier and the drug. The drug is released by the nano-carrier in a controlled fashion. B.) Optimization contour plot of the fraction of killed cells as a function of the binding affinity of the drug and the drug release rate. C.) Multi-stage drug delivery systems consist of an extra step in the delivery of nanomedicines to solid tumors including a primary nanoparticle, a secondary nanoparticle and the drug. D.) Optimization contour plot for a multi-stage delivery system (Adapted with permission from 131).