Table 1.
Agonist Pharmacology of NDP-MSH, α-MSH, and ClpB(535-548) at the Mouse Melanocortin Receptors.a
| Peptide | mMC1R | mMC3R | mMC4R | mMC5R |
|---|---|---|---|---|
|
| ||||
| EC50 (nM) | ||||
|
| ||||
| NDP-MSH | 0.019±0.006 | 0.22±0.03 | 0.34±0.09 | 0.27±0.04 |
| α-MSH | 0.14±0.04 | 0.50±0.06 | 2.9±0.5 | 0.51±0.10 |
| ClpB(535-548) | 41,000±11,000 | 30% @ 100,000 | >100,000 | 50% @ 100,000 |
a
The indicated errors represents the standard error of the mean determined from at least three independent experiments. >100,000 indicates that the compound was examined but lack agonist and antagonist activity at up to 100 μM concentrations. A percentage indicates the percent maximal stimulatory response observed at 100 μM concentrations but not enough stimulation was observed to determine an EC50 value.