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. 2015 Aug 19;309(9):C600–C607. doi: 10.1152/ajpcell.00155.2015

Fig. 7.

Fig. 7.

Inhibition of myosin 2 contraction further unmasks stabilizing role of Cx43/ZO-1 on F-actin and cell protrusions in migrating cells. A–C: baseline F-actin architecture (red) under respective treatment conditions: vehicle control (A), blebbistatin inhibition (B) of myosin 2 contraction (blebbistatin slows phosphate release from myosin 2), and Y-27632 inhibition (C) of myosin 2 contraction (Y-27632 inhibits phosphorylation of myosin light chain by Rho-kinase). D–F: effect of Cx43/ZO-1 uncoupling with αCT1 in the context of respective baseline conditions. Arrowheads indicate examples of cell separation. Nuclei are shown in blue.