Fig. 3.

Systemic serum fructose and blood glucose concentrations as a function of portal serum fructose (A) and blood glucose (B) concentrations, respectively, in wild-type mice. Systemic fructose was not significantly linked to portal fructose, but systemic glucose varied strongly with portal glucose. Similar analyses were conducted using KHK^−/− mice (C and D). Systemic fructose was significantly linked to portal fructose in KHK^−/− mice. Unlike wild-type mice, systemic was independent of portal glucose in KHK^−/− mice.