Table 1.
Overview of different experimental approaches to studies of serum fructose concentrations
| Model | Purpose | Dieta | |
|---|---|---|---|
| Study I | |||
| IA | Wild-type mice | Role of transport and metabolism on postprandial fructose levels in the portal and systemic circulations | 20% Free fructose with 10% sucrose |
| IB | KHK−/− mice | ||
| IC | GLUT5−/− mice | ||
| Study II | Wild-type and KHK−/− mice | Chronic effects of diet on HbA1c and glycemia in systemic | 20% Free fructose with 10% sucrose |
| Study III | |||
| IIIA | Wild-type and KHK−/− mice | Effect of fructose dose | 40% Free fructose |
| IIIB | Wild type | Effect of fructose dose over 7 days | 40% Free fructose |
| Study IV | |||
| IVA | Rats | Effect of duration, 5 and 30 days; comparative | 63% Free fructose |
| IVB | Rats | Effect of dose; compare with mice | 40% Free fructose |
| IVC | Rats | Effect of intestinal fructose perfusion on portal and systemic | 50 mM fructose in modified Ringer solution |
| Study V | Horse, cat, goat | Effect of feeding habit on fasting fructose | Regular diet before overnight fast |
KHK, ketohexokinase.
a
The control diet was always isocaloric, isonitrogenous, and isosmotic (where applicable) glucose.