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. 2015 Sep 4;309(9):L970–L982. doi: 10.1152/ajplung.00041.2015

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Copyright © 2015 the American Physiological Society

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Fig. 8. — Ligands for FFAR1/FFAR4 (oleic acid, linoleic acid, or GW9508) potentiated acetylcholine-induced contractions in guinea pig tracheal rings. A: representative tension tracing in guinea pig tracheal ring illustrating potentiation of acetylcholine (EC₅₀) contraction by the natural ligands for FFAR1/FFAR4 (oleic acid or linoleic acid; 20 μM each) or the_FFAR1/FFAR4-selective agonist GW9508 (20 μM). B: oleic acid, linoleic acid, or GW9508 significantly potentiated the acetylcholine (EC₅₀)-induced contraction, whereas the highly selective FFAR4 agonist TUG-891 (20 μM) did not potentiate the contraction. Data are means ± SE. *P < 0.05 compared with vehicle (0.1% DMSO) control. Numbers of experiments are shown in parentheses.