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. 2015 Aug 28;309(9):L1009–L1017. doi: 10.1152/ajplung.00386.2014

Fig. 5.

Fig. 5.

Effect of decoy peptides that block eNOS interactions with Hsp90 (TSB2) and porin (PDP) on the response to ATP in conduit size (A and C) and resistance size (B and D) pulmonary arteries. TSB2 (10−5 M) attenuated the relaxation response of conduit size pulmonary artery rings (A) and the dilator response of resistance size arterioles (B). The attenuated response was improved by Mito-Q (10−9 M). PDP (10−5 M) similarly attenuated the response to ATP in pulmonary artery rings and resistance size arterioles (C and D); mitochondrial-targeted ubiquinone (Mito-Q; 10−9 M) improved this attenuated response. *P < 0.05, from −8 M dose of ATP, and ΨP < 0.05, from control peptide group, by ANOVA and Newman Keuls test for n = 8 for ring studies and n = 6 for resistance size artery studies.