Fig. 6.
Effect of decoy peptides on tube formation by PAEC in Matrigel. Decoy peptides blocking eNOS interactions with porin (PDP; A) and Hsp90 (TSB2; B) attenuated the tube formation by PAEC in Matrigel. Summarized data are shown for tube length (C) and branch point number (D) as means ± SD from 6 experiments. Both N-acetyl cysteine (NAC) at 10−4 M and mitochondrial-targeted Mito-Q at 10−9 M restored the tube formation in decoy peptide treated cells, suggesting that increase in oxidative stress by decoy peptides impairs tube formation. *P < 0.05, from control peptide-treated cells by ANOVA and Newman Keuls test.